Ganong’s Review of Medical Physiology 26th Edition
It is difficult to believe that this preface signifies the fourth edition of Ganong’s Review of Medical Physiology that our author group has overseen, and the 26th edition overall of this important reference work aimed at medical and other health professional students. As always, we have tried to maintain the highest standards of excellence that were promulgated by the original author, Fran Ganong, over the 46 years where he served, remarkably, as the sole author of the textbook.
In this new edition, we have cast a fresh eye on the pedagogical approach taken in each chapter and section, and have focused particularly on including only material that is of the highest yield. We have thoroughly revised the learning objectives for every chapter, reorganized and updated the text to ensure that all objectives are clearly addressed in a logical order, aligned chapter summaries so that the take-home messages quickly address each learning objective in turn, and expanded the number of review questions so that readers also have the ability to check their understanding and retention of every objective covered. As a discipline evolves and new information emerges, there is a tendency simply to concatenate these concepts such that chapter structure degrades inevitably over time. With in-depth discussions amongst the author team and significant “spring-cleaning,” we believe we have freshened and simplified the volume while also making sure that important new developments are incorporated. We are immensely thankful to Erica Wehrwein, Ph.D., Assistant Professor of Physiology, and an award-winning instructor at Michigan State University, who took on the task of reviewing the book as a whole and providing specific and detailed feedback to us on each chapter.
This new edition also welcomes a new member to the author team. We are delighted to have been able to recruit Jason X.-J. Yuan, MD, Ph.D., Professor of Medicine and Physiology as well as Chief of the Division of Translational and Regenerative Medicine and Associate Vice President for Translational Health Sciences at the University of Arizona, who has assumed responsibility for some cell physiology and cardiovascular topics, as well as the respiratory physiology section. We are particularly excited to have a physician-scientist on the team, who can guide us overall to focus on the material that is of most benefit to those preparing for a career incorporating patient care. We are most grateful for the past contributions of Scott Boitano, Ph.D., whose other obligations meant that he could no longer serve as an author.
We continue to be gratified by the many colleagues and students who contact us from all over the world to request clarification of material covered in the text or to point out errors or omissions. We are especially grateful to Rajan Pandit, Lecturer in Physiology at Nepal Medical College, who has painstakingly offered dozens of suggestions for revision over the years. His efforts, and those of the many others whom we have not named, allow us to engage in a process of continual improvement. While, as always, any errors that remain in the book (inevitable in a complex project such as this) are the sole responsibility of the authorship team, we greatly value critical input and urge readers once again to contact us with any suggestions or critiques. We thank you in advance both for such feedback and also for your support of this new edition.
The leading text on human physiology for more than four decades.
For more than four decades, Ganong’s Review of Medical Physiology has been helping those in the medical field understand human and mammalian physiology. Applauded for its interesting and engagingly written style, Ganong’s concisely covers every important topic without sacrificing depth or readability and delivers more detailed, high-yield information per page than any other similar text or review.
Thoroughly updated to reflect the latest research and developments in important areas such as chronic pain, reproductive physiology, and acid-base homeostasis, Ganong’s Review of Medical Physiology, Twenty-Sixth Edition incorporates examples from clinical medicine to illustrate important physiologic concepts. Ganong’s will prove valuable to students who need a concise review for the USMLE, or physicians who want to keep pace with the ever-changing world of medical physiology.
• More than 600 full-color illustrations
• Two types of review questions: end-of-chapter and board-style
• NEW! Increased number of clinical cases and flow charts
Table of contents
SECTION I Cellular & Molecular Basis for Medical Physiology
1 General Principles & Energy Production in Medical Physiology
2 Overview of Cellular Physiology
3 Immunity, Infection, & Inflammation
4 Excitable Tissue: Nerve
5 Excitable Tissue: Muscle
6 Synaptic & Junctional Transmission
7 Neurotransmitters & Neuromodulators
SECTION II Central & Peripheral Neurophysiology
8 Somatosensory Neurotransmission: Touch, Pain, & Temperature
9 Smell & Taste
11 Hearing & Equilibrium
12 Reflex & Voluntary Control of Posture & Movement
13 Autonomic Nervous System
14 Electrical Activity of the Brain, Sleep-Wake States, & Circadian Rhythms
15 Learning, Memory, Language, & Speech
SECTION III Endocrine & Reproductive Physiology
16 Basic Concepts of Endocrine Regulation
17 Hypothalamic Regulation of Hormonal Functions
18 The Pituitary Gland
19 The Adrenal Medulla & Adrenal Cortex
20 The Thyroid Gland
21 Hormonal Control of Calcium & Phosphate Metabolism & the Physiology of Bone
22 Reproductive Development & Function of the Female Reproductive System
23 Function of the Male Reproductive System
24 Endocrine Functions of the Pancreas & Regulation of Carbohydrate Metabolism
SECTION IV Gastrointestinal Physiology
25 Overview of Gastrointestinal Function & Regulation
26 Digestion & Absorption of Nutrients
27 Gastrointestinal Motility
28 Transport & Metabolic Functions of the Liver
SECTION V Cardiovascular Physiology
29 Origin of the Heartbeat & the Electrical Activity of the Heart
30 The Heart as a Pump
31 Blood as a Circulatory Fluid & the Dynamics of Blood & Lymph Flow
32 Cardiovascular Regulatory Mechanisms
33 Circulation Through Special Regions
SECTION VI Respiratory Physiology
34 Introduction to Pulmonary Structure & Mechanics
35 Gas Transport & pH
36 Regulation of Respiration
SECTION VII Renal Physiology
37 Renal Function & Micturition
38 Regulation of Extracellular Fluid Composition & Volume
39 Acidification of the Urine & Bicarbonate Excretion
Answers to Multiple Choice Questions
About the author:
Kim E. Barrett, Ph.D. Professor of Medicine and Dean of Graduate Studies University of California, San Diego – School of Medicine.
Kim Barrett received her Ph.D. in biological chemistry from University College London in 1982. Following postdoctoral training at the National Institutes of Health, she joined the faculty at the University of California, San Diego, School of Medicine in 1985, rising to the rank of Professor of Medicine in 1996, and was named Distinguished Professor of Medicine in 2015.
From 2006 to 2016, she also served the University as Dean of the Graduate Division. Her research interests focus on the physiology and pathophysiology of the intestinal epithelium, and how its function is altered by commensal, probiotic, and pathogenic bacteria as well as in specific disease states, such as inflammatory bowel diseases.
She has published more than 250 articles, chapters, and reviews, and has received several honors for her research accomplishments including the Bowditch and Davenport Lectureships from the American Physiological Society (APS), the Bayliss-Starling Lectureship from The Physiological Society of the UK and Ireland, and the degree of Doctor of Medical Sciences, honoris causa, from Queens University, Belfast. She has been very active in scholarly editing, serving currently as the Editor-in-Chief of the Journal of Physiology.
She is also a dedicated and award-winning instructor of medical, pharmacy, and graduate students, and has taught various topics in medical and systems physiology to these groups for more than 30 years. Her efforts as a teacher and mentor were recognized with the Bodil M. Schmidt- Nielson Distinguished Mentor and Scientist Award from the APS in 2012, and she also served as the 86th APS President from 2013 to 2014. Her teaching experiences led her to author a prior volume (Gastrointestinal Physiology, McGraw-Hill, 2005; second edition published in 2014) and she was honored to have been invited to take over the helm of Ganong in 2007 for the 23rd and subsequent editions, including this one.
Heddwen L Brooks, Ph.D. Professor, Physiology Associate Professor, Pharmacology Professor, Medicine Professor, Physiological Sciences – GIDP Professor, Biomedical Engineering Professor, BIO5 Institute University of Arizona, Tuscon – School of Medicine.
Heddwen Brooks received her Ph.D. from Imperial College, University of London, and is a Professor in the Departments of Physiology and Pharmacology at the University of Arizona (UA). Dr. Brooks is a renal physiologist and is best known for her development of microarray technology to address in vivo signaling pathways involved in the hormonal regulation of renal function.
Dr. Brooks’ many awards include the American Physiological Society (APS) Lazaro J. Mandel Young Investigator Award, which is for an individual demonstrating outstanding promise in epithelial or renal physiology. In 2009, Dr. Brooks received the APS Renal Young Investigator Award at the annual meeting of the Federation of American Societies for Experimental Biology. Dr. Brooks served as Chair of the APS Renal Section (2011–2014) and currently serves as Associate Editor for the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, and on the Editorial Board for the American Journal of Physiology-Renal Physiology (since 2001). Dr. Brooks has served on study sections of the National Institutes of Health, the American Heart Association, and served as a member of the Nephrology Merit Review Board for the Department of Veterans’ Affairs.
Susan Barman, Ph.D., FAPS Professor, Pharmacology & Toxicology Michigan State University.
Susan Barman received her Ph.D. in physiology from Loyola University School of Medicine in Maywood, Illinois. Afterward, she went to Michigan State University (MSU) where she is currently a Professor in the Department of Pharmacology/Toxicology and the Neuroscience Program. She is also Chair of the Institutional Animal Care and Use Committee and serves on the College of Human Medicine (CHM) Curriculum Development Group for medical school education. She has had a career-long interest in the neural control of cardiorespiratory function with an emphasis on the characterization and origin of the naturally occurring discharges of sympathetic and phrenic nerves.
She has published about 150 research articles, invited review articles, and book chapters. She was a recipient of a prestigious National Institutes of Health MERIT (Method to Extend Research in Time) Award. She is also a recipient of an MSU Outstanding University Woman Faculty Award, a CHM Distinguished Faculty Award, a Distinguished Service Award from the Association of Chairs of Departments of Physiology, and the Carl Ludwig Distinguished Lecture Award from the Neural Control of Autonomic Regulation section of the American Physiological Society (APS). She is also a Fellow of the APS and served as its 85th President. She has also served as a Councilor of APS and Chair of the Women in Physiology and Section Advisory Committees of the APS. She is also active in the Michigan Physiological Society, a chapter of the APS.
Jason Yuan Professor of Medicine Associate Director for Research Training (Basic Science) University of California, San Diego – School of Medicine.
Jason Yuan received his medical degree from Suzhou Medical College (Suzhou, China) in 1983, his doctoral degree in cardiovascular physiology from Peking Union Medical College (Beijing, China), and his postdoctoral training at the University of Maryland at Baltimore. He joined the faculty at the University of Maryland School of Medicine in 1993 and then moved to the University of California, San Diego in 1999, rising to the rank of Professor in 2013.
His research interests center on the pathogenic roles of membrane receptors and ion channels in pulmonary vascular disease. He has published more than 300 articles, reviews, editorials, and chapters, and has edited or co-edited nine books. He has received several honors for his research accomplishments including the Cournand and Comroe Young Investigator Award, the Established Investigator Award and the Kenneth D. Bloch Memorial Lectureship from the American Heart Association; the Guggenheim Fellowship Award from the John Simon Guggenheim Memorial Foundation; the Estelle Grover Lectureship from the American Thoracic Society; and the Robert M. Berne Memorial Lectureship from The American Physiological Society. He is an elected Fellow of the American Association for the Advancement of Science and an elected Member of the American Society for Clinical Investigation and the Association of American Physicians.
He has served on many advisory committees including Chair of the Respiratory Integrative Biology and Translational Research study section of the National Institutes of Health and Chair of the Pulmonary Circulation Assembly of the American Thoracic Society. He has also been very active in scholarly editing serving currently as the Editor-in-Chief of the journal Pulmonary Circulation and Associate Editor of the American Journal of Physiology-Cell Physiology. He is a leading editor of the Textbook of Pulmonary Vascular Disease (Springer, 2011).
Reviews about the ebook:
- Christopher Bonner:
Very thorough for board reviews.
- Kathy Gerken:
Easy to read and follow. Just enough detail without being overly cumbersome.
- Oswin L. Sathiamoses:
It’s an international standards textbook on the subject and there is nothing to review on that I guess.
E-version is user-friendly. I’ve used it on Kindle paperwhite, on Kindle for windows pc, and Kindle for Android. Quite usable.
Great book but not for beginners.
- Roberto Galindo:
This reads like a novel, can’t let it down. So well researched.
- Ranita Terror:
My favorite book for medical physiology!
- Dr. Mustafizur:
For Higher Education like Post Graduation NEET PG.
Also for Reference in MBBS.
As the title rightly says, it is a review book. I could not make much sense when I first read the book in my first year of medical school. There are few gaps in concepts, there isn’t exactly a flow like in Guyton. But when I picked it up again in my final year, it was beautiful. Every line written in Ganong is there for a reason. If you pay sufficient attention while reading, there is more you can derive from the text and the diagrams. There is so much in between the lines. Particularly loved the chapters on cardiac and renal physiology. Highly recommend it to be read at least once.
- Çağlayan Taybaş:
1990’ların televizyon kültürü ekrandan izleyiciye tek yönlü bir bilgi akışı sunuyordu. Bilgisayarların, akıllı telefonların yaygınlaşmasıyla beraber bu durum değişti. Artık transmedya var. Televizyon, internet, oyunlar, karikatürler hepsi birlikte etkileşimli medyayı oluşturuyor.
I read the latest and greatest every year they are published. Another outstanding read.
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