Harrison’s Principles of Internal Medicine 20th Edition Volume I & II


Harrison’s Principles of Internal Medicine, 20th Edition Volume I & II

Author: Dennis L. Kasper,
Anthony S. Fauci,
Stephen L. Hauser,
Dan L. Longo,
J. Larry Jameson,
Joseph Loscalzo.
Edition: 20th Edition
Year: 2018
Language: English
ISBN 13: 9781259644030
Publisher: McGraw-Hill Education
ISBN 10: 1259644030
Pages: 4100
File: PDF
Price: 15.99$
Digital delivery: Via Email check your SPAM

Harrison’s Principles of Internal Medicine 20th Edition Volume I & II

Introducing the Landmark Twentieth Edition of the Global Icon of Internal Medicine

The definitive guide to internal medicine is more essential than ever with the latest in disease mechanisms, updated clinical trial results and recommended guidelines, state of the art radiographic images, therapeutic approaches, and specific treatments, hundreds of demonstrative full-color drawings, and practical clinical decision trees and algorithms

A Doody’s Core Title for 2019!

Recognized by healthcare professionals worldwide as the leading authority on applied pathophysiology and clinical medicine, Harrison’s Principles of Internal Medicine gives you the informational foundation you need to provide the best patient care possible.

Essential for practice and education, the landmark 20th Edition features:

  • Thoroughly revised content―covering the many breakthroughs and advances in clinical medicine that have occurred since the last edition of Harrison’s. Chapters on acute and chronic hepatitis, management of diabetes, immune-based therapies in cancer, multiple sclerosis, cardiovascular disease, HIV, and many more, deliver the very latest information on disease mechanisms, diagnostic options, and the specific treatment guidance you need to provide optimal patient care.
  • State of the art coverage of disease mechanisms: Harrison focuses on pathophysiology with rigor, and aims to link disease mechanisms to treatments. Improved understanding of how diseases develop and progress promotes better decision-making and higher-value care and makes for fascinating reading and improved retention. Harrison’s summarizes important new basic science developments, such as the role of mitochondria in programmed and necrotic cell death, the immune system’s role in cancer development and treatment, the impact of telomere shortening in the aging and disease processes, and the role of the microbiome in health and disease.
  • Understanding the role of inflammation in cardiovascular disease, the precise mechanisms of immune deficiency in HIV/AIDS, prions and misfolded proteins in neurodegenerative diseases, and obesity as a predisposition to diabetes are just a few examples of how this edition provides essential pathophysiology information for health professionals.
  • All-new sections covering a wide range of new and emerging areas of vital interest to all healthcare professionals. New sections include Sex and Gender-based Issues in Medicine; Obesity, Diabetes Mellitus, and Metabolic Syndrome; and Consultative Medicine― Plus, a new Part covering cutting edge topics in research and clinical medicine includes great new chapters on the role of Epigenetics in Health and Disease, Behavioral Strategies to Improve Health, Genomics and Infectious Diseases, Emerging Neuro Therapeutic Technologies, and Telomere Function in Health and Disease, and Network System Medicine.
    Important and timely new chapters―such as Promoting Good Health, LGBT Health, Systems of Healthcare, Approach to Medical Consultation, Pharmacogenomics, Antimicrobial Resistance, Worldwide Changes in Patterns of Infectious Diseases, Neuromyelitis Optica, and more―offer the very latest, definitive perspectives on must-know topics in medical education and practice.
  • Updated clinical guidelines, expert opinions, and treatment approaches from renowned editors and authors contribute to the accuracy and immediacy of the text material and present a clear blueprint for optimizing patient

ISBN: 978-1-25-964404-7
MHID: 1-25-964404-9

ISBN: 978-1-25-964403-0
MHID: 1-25-964403-0


FIG. 464-5 Algorithm depicting assessment and management of falls in older patients
FIG. 464-7 Algorithm depicting assessment and management of delirium in hospitalized older patients
FIG. 345-4 Algorithm for the diagnosis and management of rhinitis
FIG. 349-2 Algorithm for diagnosis and initial therapy of systemic lupus erythematosus
FIG. 354-1 Treatment algorithm for Sjögren’s syndrome
FIG. 355-2 Algorithm for the diagnosis or exclusion of axial spondyloarthritis
FIG. 356-1 Algorithm for the approach to a patient with a suspected diagnosis of vasculitis
FIG. 360-8 Proposed approach to the management of a patient with possible sarcoidosis
FIG. 360-9 The management of acute sarcoidosis is based on the level of symptoms and extent of organ involvement
FIG. 360-10 Approach to chronic disease
FIG. 363-1 Algorithm for the diagnosis of musculoskeletal complaints
FIG. 363-2 Algorithm for consideration of the most common musculoskeletal conditions
FIG. 363-6 Algorithmic approach to the use and interpretation of synovial fluid aspiration and analysis.
FIG. 37-1 Clinical condition in which a decrease in cardiac output and systemic vascular resistance causes arterial underfilling with resulting neurohumoral activation and renal sodium and water retention
FIG. 38-5 Differential diagnosis of a holosystolic murmur
FIG. 38-9 Strategy for evaluating heart murmurs
FIG. 231-1 Approach to the evaluation of a heart murmur
FIG. 244-6 Treatment algorithm for patients presenting with hemodynamically stable paroxysmal supraventricular tachycardia.
FIG. 254-18 Treatment algorithm for hypertrophic cardiomyopathy
FIG. 256-4 Management strategy for patients with aortic stenosis
FIG. 257-1 Management of patients with aortic regurgitation
FIG. 258-1 Management of rheumatic mitral stenosis
FIG. 259-1 Management of mitral regurgitation
FIG. 261-1 Management of tricuspid regurgitation
FIG. 267-3 Evaluation of the patient with known or suspected ischemic heart disease.
FIG. 267-4 Algorithm for management of a patient with ischemic heart disease.
FIG. 268-3 Algorithm for evaluation and management of patients with suspected acute coronary syndrome
FIG. 269-5 Algorithm for assessment of the need for implantation of a cardioverter-defibrillator
FIG. 467-1 Composite algorithm for cardiac risk assessment and stratification in patients undergoing noncardiac surgery.
FIG. 67-6 Algorithm for genetic testing in a family with cancer predisposition.
FIG. 457-2 Approach to genetic testing
FIG. 472-9 Clinical and laboratory investigation of a suspected mitochondrial DNA disorder.
FIG. 269-4 Reperfusion therapy for patients with ST-segment elevation myocardial infarction
FIG. 307-2 A typical algorithm for early post-transplant care of a kidney recipient.
FIG. 293-2 Approach to the patient in shock.
FIG. 294-5 Algorithm for the initial management of ARDS.
FIG. 295-2 Algorithm to guide the daily approach to the management of patients being considered for weaning off mechanical ventilation
FIG. 298-2 Emergency management of patients with cardiogenic shock.
FIG. 299-3A Algorithm for the approach to cardiac arrest due to VT or VF (shockable rhythm).
FIG. 299-3B Algorithm for the approach to cardiac arrest due to bradyarrhythmias/asystole and pulseless electrical activity
FIG. S4-1 General guidelines for the treatment of radiation casualties.
FIG. S4-2 Algorithm for evacuation in a multi-casualty radiologic event.
FIG. 372-1 Management of adult growth hormone deficiency.
FIG. 373-3 Management of prolactinoma
FIG. 373-5 Management of acromegaly.
FIG. 373-6 Management of Cushing’s disease.
FIG. 373-7 Management of a nonfunctioning pituitary mass.
FIG. 376-2 Evaluation of hypothyroidism.
FIG. 377-2 Evaluation of thyrotoxicosis.
FIG. 378-4 Approach to the patient with a thyroid nodule.
FIG. 379-10 Management of the patient with suspected Cushing’s syndrome.
FIG. 379-12 Management of patients with suspected mineralocorticoid excess.
FIG. 379-13 Management of the patient with an incidentally discovered adrenal mass.
FIG. 379-16 Management of the patient with suspected adrenal insufficiency.
FIG. 384-5 Evaluation of gynecomastia.
FIG. 384-6 Evaluation of hypogonadism.
FIG. 387-2 Algorithm for the evaluation and differential diagnosis of hirsutism.
FIG. 388-4 Algorithm for menopausal symptom management.
FIG. 390-3 Algorithm for the evaluation and management of patients with erectile dysfunction.
FIG. 395-1 Treatment algorithm—chronic disease management model for primary care of patients with overweight and obesity.
FIG. 397-2 Essential elements in the comprehensive care of type 2 diabetes.
FIG. 397-3 Glycemic management of type 2 diabetes.
FIG. 398-4 Screening for albuminuria.
FIG. 399-2 Hypoglycemia-associated autonomic failure in insulin-deficient diabetes.
FIG. 403-6 Algorithm for the evaluation of patients with hypercalcemia.
FIG. 407-3 Algorithm for screening for HFE-associated hemochromatosis.
FIG. 40-2 Approach to the patient with dysphagia.
FIG. 42-2 Algorithm for the management of acute diarrhea.
FIG. 42-3 Algorithm for management of chronic diarrhea.
FIG. 42-4 Algorithm for the management of constipation.
FIG. 44-1 Suggested algorithm for patients with acute upper gastrointestinal bleeding based on endoscopic findings.
FIG. 44-2 Suggested algorithm for patients with acute lower gastrointestinal bleeding.
FIG. 45-1 Evaluation of the patient with jaundice.
FIG. 46-3 Algorithm for the diagnosis of ascites according to the serum-ascites albumin gradient
FIG. 317-12 Approach to selecting antibiotics for patients with H. pylori infection
FIG. 317-13 Overview of new-onset dyspepsia
FIG. 329-1 Algorithm for evaluation of abnormal liver tests.
FIG. 330-1 Algorithm for the evaluation of chronically abnormal liver tests.
FIG. 335-2 Treatment algorithm for alcoholic hepatitis.
FIG. 337-3 Management of recurrent variceal hemorrhage.
FIG. 337-5 Treatment of refractory ascites.
FIG. 340-1 A stepwise diagnostic approach to the patient with suspected chronic pancreatitis
FIG. 59-17 The physiologic classification of anemia.
FIG. 59-18 An approach to the differential diagnosis of patients with elevated hemoglobin (possible polycythemia).
FIG. 70-2 Algorithm for the diagnosis and treatment of fever and neutropenia.
FIG. 71-2 Management of cancer patients with back pain.
FIG. 71-4 Management of patients at high risk for tumor lysis syndrome.
FIG. 73-1 Evaluation of a patient with cervical adenopathy.
FIG. 74-3 Algorithm for management of non-small-cell lung cancer.
FIG. 74-5 Algorithm for management of small-cell lung cancer.
FIG. 74-6A Algorithm for evaluation of solitary pulmonary nodule.
FIG. 74-6B Algorithm for evaluation of solid pulmonary nodule.
FIG. 74-6C Algorithm for evaluation of semisolid solid pulmonary nodule.
FIG. 74-7 Management of recurrent small-cell lung cancer
FIG. 74-8 Approach to first-line therapy in a patient with stage IV non-small-cell lung cancer
FIG. 78-8 Staging and treatment schedule for Intrahepatic cholangiocarcinoma proposed by the International Liver Cancer Association.
FIG. 88-2 Treatment algorithm for adenocarcinoma and poorly differentiated adenocarcinoma of unknown primary
FIG. 88-3 Treatment algorithm for squamous cell carcinoma of unknown primary.
FIG. 94-3 Pathophysiology of sickle cell crisis.
FIG. 100-2 Algorithm for the therapy of newly diagnosed acute myeloid leukemia.
FIG. 107-6 Treatment algorithm for multiple myeloma.
FIG. 108-1 Algorithm for the diagnosis of amyloidosis and determination of type.
FIG. 111-2 Algorithm for evaluating the thrombocytopenic patient.
FIG. 114-1 Classification of antithrombotic drugs.
FIG. 31-2 Algorithm for the diagnosis and treatment of acute pharyngitis.
FIG. 123-4 The diagnostic use of transesophageal and transtracheal echocardiography.
FIG. 127-3 Algorithm for the management of patients with intraabdominal abscesses by percutaneous drainage.
FIG. 128-1 Clinical algorithm for the approach to patients with community-acquired infectious diarrhea or bacterial food poisoning.
FIG. 130-4 Diagnostic approach to urinary tract infection.
FIG. 147-1 Clinical and pathologic progression of tetanus.
FIG. 158-1 Schematic of the relationships between colonization with Helicobacter pylori and diseases of the upper gastrointestinal tract.
FIG. 158-2 Algorithm for the management of Helicobacter pylori infection.
FIG. 180-3 Algorithm for treatment of relapsing fever.
FIG. 181-2 Algorithm for the treatment of the various early or late manifestations of Lyme borreliosis.
FIG. 197-33 Algorithm for the acute HIV syndrome.
FIG. 197-37 Algorithm for the evaluation of diarrhea in a patient with HIV infection.
FIG. 203-6 Algorithm for rabies postexposure prophylaxis.
FIG. S5-1 Syndromic approach to the differential diagnosis of suspected infection in a veteran who has returned from a foreign war.
FIG. 48-1 Approach to the patient with azotemia.
FIG. 48-2 Approach to the patient with hematuria.
FIG. 48-3 Approach to the patient with proteinuria.
FIG. 48-4 Approach to the patient with polyuria.
FIG. 49-5 The diagnostic approach to hyponatremia.
FIG. 49-6 The diagnostic approach to hypernatremia.
FIG. 49-7 The diagnostic approach to hypokalemia.
FIG. 49-8 The diagnostic approach to hyperkalemia.
FIG. 307-2 A typical algorithm for early posttransplant care of a kidney recipient.
FIG. 310-1 Algorithm for the treatment of allergic and other immune-mediated acute interstitial nephritis.
FIG. 313-1 Diagnostic approach for urinary tract obstruction in unexplained renal failure.
FIG. 133-1 The pathophysiology of the neurologic complications of bacterial meningitis.
FIG. 418-2 Evaluation of the adult patient with a seizure.
FIG. 418-5 Pharmacologic treatment of generalized tonic-clonic status epilepticus in adults.
FIG. 419-1 Medical management of stroke and TIA.
FIG. 427-7 Treatment options for the management of Parkinson’s disease.
FIG. 436-4 Therapeutic decision-making for relapsing multiple sclerosis.
FIG. 438-1 Approach to the evaluation of peripheral neuropathies.
FIG. 440-2 Algorithm for the management of myasthenia gravis.
FIG. 441-1 Diagnostic evaluation of intermittent weakness.
FIG. 441-2 Diagnostic evaluation of persistent weakness.
FIG. 444-1 A guideline for the medical management of the major depressive disorder.
FIG. 33-2 Possible algorithm for the evaluation of the patient with dyspnea.
FIG. 35-1 Approach to the management of hemoptysis.
FIG. 273-3 How to decide whether diagnostic imaging is needed.
FIG. 273-6 Imaging tests to diagnose DVT and PE.
FIG. 273-7 Acute management of pulmonary thromboembolism.
FIG. 288-1 Approach to the diagnosis of pleural effusions.
FIG. 17-1 Structured approach to patients with fever of unknown origin.
FIG. 21-3 An algorithm for the initial workup of a patient with weakness.
FIG. 30-2 An algorithm for the approach to hearing loss.
FIG. 57-1 Algorithm for the diagnosis of a patient with photosensitivity.
FIG. 386-2 Algorithm for evaluation of amenorrhea.

Harrison’s Principles of Internal Medicine 20th Edition Volume I & II.

Table of Contents:

PART 1 The Profession of Medicine
1 The Practice of Medicine.
The Editors
2 Promoting Good Health.
Donald M. Lloyd-Jones, Kathleen M. McKibbin
3 Decision-Making in Clinical Medicine.
Daniel B. Mark, John B. Wong
4 Screening and Prevention of Disease.
Katrina A. Armstrong, Gary J. Martin
5 Health Care Systems in Developed Countries.
Richard B. Saltman
6 The Safety and Quality of Health Care.
David W. Bates
7 Racial and Ethnic Disparities in Health Care.
Joseph R. Betancourt, Alexander R. Green
8 Ethical Issues in Clinical Medicine.
Bernard Lo, Christine Grady
9 Palliative and End-of-Life Care.
Ezekiel J. Emanuel
PART 2 Cardinal Manifestations and Presentation of Diseases
10 Pain: Pathophysiology and Management.
James P. Rathmell, Howard L. Fields
11 Chest Discomfort.
David A. Morrow
12 Abdominal Pain.
Danny O. Jacobs
13 Headache.
Peter J. Goadsby
14 Back and Neck Pain.
John W. Engstrom
SECTION 2 Alterations in Body Temperature
15 Fever.
Charles A. Dinarello, Reuven Porat
16 Fever and Rash.
Elaine T. Kaye, Kenneth M. Kaye
17 Fever of Unknown Origin.
Chantal P. Bleeker-Rovers, Jos W. M. van der Meer
SECTION 3 Nervous System Dysfunction
18 Syncope.
Roy Freeman
19 Dizziness and Vertigo.
Mark F. Walker, Robert B. Daroff
20 Fatigue.
Jeffrey M. Gelfand, Vanja C. Douglas
21 Neurologic Causes of Weakness and Paralysis.
Michael J. Aminoff
22 Numbness, Tingling, and Sensory Loss.
Michael J. Aminoff
23 Gait Disorders, Imbalance, and Falls.
Jessica M. Baker, Lewis R. Sudarsky
24 Confusion and Delirium.
S. Andrew Josephson, Bruce L. Miller
25 Dementia.
William W. Seeley, Bruce L. Miller
26 Aphasia, Memory Loss, Hemispatial Neglect,
Frontal Syndromes, and Other Cerebral Disorders.
M.-Marsel Mesulam
27 Sleep Disorders.
Thomas E. Scammell, Clifford B. Saper, Charles A. Czeisler
SECTION 4 Disorders of Eyes, Ears, Nose,
and Throat
28 Disorders of the Eye.
Jonathan C. Horton
29 Disorders of Smell and Taste.
Richard L. Doty, Steven M. Bromley
30 Disorders of Hearing.
Anil K. Lalwani
31 Sore Throat, Earache, and Upper Respiratory Symptoms.
Michael A. Rubin, Larry C. Ford, Ralph Gonzales
32 Oral Manifestations of Disease.
Samuel C. Durso
SECTION 5 Alterations in Circulatory and
Respiratory Functions
33 Dyspnea.
Rebecca M. Baron
34 Cough.
Christopher H. Fanta
35 Hemoptysis.
Anna K. Brady, Patricia A. Kritek
36 Hypoxia and Cyanosis.
Joseph Loscalzo
37 Edema.
Eugene Braunwald, Joseph Loscalzo
38 Approach to the Patient with a Heart Murmur.
Patrick T. O’Gara, Joseph Loscalzo
39 Palpitations.
Joseph Loscalzo
SECTION 6 Alterations in Gastrointestinal Function
40 Dysphagia.
Ikuo Hirano, Peter J. Kahrilas
41 Nausea, Vomiting, and Indigestion.
William L. Hasler
42 Diarrhea and Constipation.
Michael Camilleri, Joseph A. Murray
43 Unintentional Weight Loss.
J. Larry Jameson
44 Gastrointestinal Bleeding.
Loren Laine
45 Jaundice.
Savio John, Daniel S. Pratt
46 Abdominal Swelling and Ascites.
Kathleen E. Corey, Lawrence S. Friedman
SECTION 7 Alterations in Renal and Urinary
Tract Function
47 Dysuria, Bladder Pain, and the Interstitial
Cystitis/ Bladder Pain Syndrome.
John W. Warren
48 Azotemia and Urinary Abnormalities.
David B. Mount
49 Fluid and Electrolyte Disturbances.
David B. Mount
50 Hypercalcemia and Hypocalcemia.
Sundeep Khosla
51 Acidosis and Alkalosis.
Thomas D. DuBose, Jr.
SECTION 8 Alterations in the Skin
52 Approach to the Patient with a Skin Disorder.
Kim B. Yancey, Thomas J. Lawley
53 Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders.
Leslie P. Lawley, Calvin O. McCall, Thomas J. Lawley
54 Skin Manifestations of Internal Disease.
Jean L. Bolognia, Irwin M. Braverman
55 Immunologically Mediated Skin Diseases.
Kim B. Yancey, Thomas J. Lawley
56 Cutaneous Drug Reactions.
Robert G. Micheletti, Misha Rosenbach, Bruce U. Wintroub, Kanade Shinkai
57 Photosensitivity and Other Reactions to Light.
Alexander G. Marneros, David R. Bickers
SECTION 9 Hematologic Alterations
58 Interpreting Peripheral Blood Smears.
Dan L. Longo
59 Anemia and Polycythemia.
John W. Adamson, Dan L. Longo
60 Disorders of Granulocytes and Monocytes.
Steven M. Holland, John I. Gallin
61 Bleeding and Thrombosis.
Barbara A. Konkle
62 Enlargement of Lymph Nodes and Spleen.
Dan L. Longo
PART 3 Pharmacology
63 Principles of Clinical Pharmacology.
Dan M. Roden
64 Pharmacogenomics.
Dan M. Roden
PART 4 Oncology and Hematology
SECTION 1 Neoplastic Disorders
65 Approach to the Patient with Cancer.
Dan L. Longo
66 Prevention and Early Detection of Cancer.
Jennifer M. Croswell, Otis W. Brawley, Barnett S. Kramer
67 Cancer Genetics.
Fred Bunz, Bert Vogelstein
68 Cancer Cell Biology.
Jeffrey W. Clark, Dan L. Longo
69 Principles of Cancer Treatment.
Edward A. Sausville, Dan L. Longo
70 Infections in Patients with Cancer.
Robert W. Finberg
71 Oncologic Emergencies.
Rasim Gucalp, Janice P. Dutcher
72 Cancer of the Skin.
Brendan D. Curti, Sancy Leachman, Walter J. Urba
73 Head and Neck Cancer.
Everett E. Vokes
74 Neoplasms of the Lung.
Leora Horn, Christine M. Lovly
75 Breast Cancer.
Daniel F. Hayes, Marc E. Lippman
76 Upper Gastrointestinal Tract Cancers.
Robert J. Mayer
77 Lower Gastrointestinal Cancers.
Robert J. Mayer
78 Tumors of the Liver and Biliary Tree.
Josep M. Llovet
79 Pancreatic Cancer.
Daniel D. Von Hoff
80 Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas.
Robert T. Jensen
81 Renal Cell Carcinoma.
Robert J. Motzer
82 Cancer of the Bladder and Urinary Tract.
Noah M. Hahn
83 Benign and Malignant Diseases of the Prostate.
Howard I. Scher, James A. Eastham
84 Testicular Cancer.
David J. Vaughn
85 Gynecologic Malignancies.
David Spriggs
86 Primary and Metastatic Tumors of the Nervous System.
Lisa M. DeAngelis, Patrick Y. Wen
87 Soft Tissue and Bone Sarcomas and Bone Metastases.
Shreyaskumar R. Patel
88 Carcinoma of Unknown Primary.
Gauri R. Varadhachary, James L. Abbruzzese
89 Paraneoplastic Syndromes: Endocrinologic/Hematologic.
J. Larry Jameson, Dan L. Longo
90 Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis.
Josep Dalmau, Myrna R. Rosenfeld
91 Late Consequences of Cancer and Its Treatment.
Carl E. Freter, Dan L. Longo
SECTION 2 Hematopoietic Disorders
92 Hematopoietic Stem Cells.
David T. Scadden, Dan L. Longo
93 Iron Deficiency and Other Hypoproliferative Anemias.
John W. Adamson
94 Disorders of Hemoglobin.
Edward J. Benz, Jr.
95 Megaloblastic Anemias.
A. Victor Hoffbrand
96 Hemolytic Anemias.
Lucio Luzzatto
97 Anemia Due to Acute Blood Loss.
Dan L. Longo
98 Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia.
Neal S. Young
99 Polycythemia Vera and Other Myeloproliferative Neoplasms.
Jerry L. Spivak
100 Acute Myeloid Leukemia.
William Blum, Clara D. Bloomfield
101 Chronic Myeloid Leukemia.
Hagop Kantarjian, Jorge Cortes
102 Acute Lymphoid Leukemia.
Dieter Hoelzer
103 Chronic Lymphocytic Leukemia.
Jennifer A. Woyach, John C. Byrd
104 Non-Hodgkin’s Lymphoma.
Caron A. Jacobson, Dan L. Longo
105 Hodgkin’s Lymphoma.
Caron A. Jacobson, Dan L. Longo
106 Less Common Hematologic Malignancies.
Ayalew Tefferi, Dan L. Longo
107 Plasma Cell Disorders.
Nikhil C. Munshi, Dan L. Longo, Kenneth C. Anderson
108 Amyloidosis.
John L. Berk, Vaishali Sanchorawala
109 Transfusion Biology and Therapy.
Jeffery S. Dzieczkowski, Pierre Tiberghien, Kenneth C. Anderson
110 Hematopoietic Cell Transplantation.
Frederick R. Appelbaum
SECTION 3 Disorders of Hemostasis
111 Disorders of Platelets and Vessel Wall.
Barbara A. Konkle
112 Coagulation Disorders.
Valder R. Arruda, Katherine A. High
113 Arterial and Venous Thrombosis.
Jane E. Freedman, Joseph Loscalzo
114 Antiplatelet, Anticoagulant, and Fibrinolytic Drugs.
Jeffrey I. Weitz
PART 5 Infectious Diseases
SECTION 1 Basic Considerations in Infectious Diseases
115 Approach to the Patient with an Infectious Disease.
Neeraj K. Surana, Dennis L. Kasper
116 Molecular Mechanisms of Microbial Pathogenesis.
Gerald B. Pier
117 Approach to the Acutely Ill Infected Febrile Patient.
Tamar F. Barlam, Dennis L. Kasper
118 Immunization Principles and Vaccine Use.
Nancy Messonnier, Anne Schuchat, Lisa A. Jackson
119 Health Recommendations for International Travel.
Jay S. Keystone, Phyllis E. Kozarsky
120 Climate Change and Infectious Disease.
Aaron S. Bernstein
SECTION 2 Clinical Syndromes:
Community-Acquired Infections
121 Pneumonia.
Lionel A. Mandell, Richard Wunderink
122 Lung Abscess.
Rebecca M. Baron, Miriam Baron Barshak
123 Infective Endocarditis.
Adolf W. Karchmer
124 Infections of the Skin, Muscles, and Soft Tissues.
Dennis L. Stevens
125 Infectious Arthritis.
Lawrence C. Madoff
126 Osteomyelitis.
Werner Zimmerli
127 Intraabdominal Infections and Abscesses.
Miriam Baron Barshak, Dennis L. Kasper
128 Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning.
Richelle C. Charles, Stephen B. Calderwood, Regina C. LaRocque
129 Clostridium difficile Infection, Including Pseudomembranous Colitis.
Dale N. Gerding, Stuart Johnson
130 Urinary Tract Infections, Pyelonephritis, and Prostatitis.
Kalpana Gupta, Barbara W. Trautner
131 Sexually Transmitted Infections: Overview and Clinical Approach.
Jeanne M. Marrazzo, King K. Holmes
132 Encephalitis.
Karen L. Roos, Kenneth L. Tyler
133 Acute Meningitis.
Karen L. Roos, Kenneth L. Tyler
134 Chronic and Recurrent Meningitis.
Walter J. Koroshetz, Michael R. Wilson, Avindra Nath
135 Brain Abscess and Empyema.
Karen L. Roos, Kenneth L. Tyler
136 Infectious Complications of Bites.
Sandeep S. Jubbal, Florencia Pereyra, Lawrence C. Madoff
SECTION 3 Clinical Syndromes: Health Care-Associated Infections
137 Infections Acquired in Health Care Facilities.
Robert A. Weinstein
138 Infections in Transplant Recipients.
Robert W. Finberg, Joyce D. Fingeroth
SECTION 4 Therapy for Bacterial Diseases
139 Treatment and Prophylaxis of Bacterial Infections.
David C. Hooper, Erica S. Shenoy, Christy A. Varughese
140 Bacterial Resistance to Antimicrobial Agents.
David C. Hooper
SECTION 5 Diseases Caused by Gram-Positive Bacteria
141 Pneumococcal Infections.
David Goldblatt, Katherine L. O’Brien
142 Staphylococcal Infections.
Franklin D. Lowy
143 Streptococcal Infections.
Michael R. Wessels
144 Enterococcal Infections.
Cesar A. Arias, Barbara E. Murray
145 Diphtheria and Other Corynebacterial Infections.
William R. Bishai, John R. Murphy
146 Listeria monocytogenes Infections.
Elizabeth L. Hohmann, Daniel A. Portnoy
147 Tetanus.
C. Louise Thwaites, Lam Minh Yen
148 Botulism.
Agam K. Rao, Susan Maslanka
149 Gas Gangrene and Other Clostridial Infections.
Amy E. Bryant, Dennis L. Stevens
SECTION 6 Diseases Caused by Gram-Negative Bacteria
150 Meningococcal Infections.
Andrew J. Pollard
151 Gonococcal Infections.
Sanjay Ram, Peter A. Rice
152 Haemophilus and Moraxella Infections.
Timothy F. Murphy
153 Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria.
Tamar F. Barlam, Dennis L. Kasper
154 Legionella Infections.
Victor L. Yu, M. Luisa Pedro-Botet, Yusen E. Lin
155 Pertussis and Other Bordetella Infections.
Karina A. Top, Scott A. Halperin
156 Diseases Caused by Gram-Negative Enteric Bacilli.
Thomas A. Russo, James R. Johnson
157 Acinetobacter Infections.
Rossana Rosa, L. Silvia Munoz-Price
158 Helicobacter pylori Infections.
John C. Atherton, Martin J. Blaser
159 Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species.
Reuben Ramphal
160 Salmonellosis.
David A. Pegues, Samuel I. Miller
161 Shigellosis.
Philippe J. Sansonetti, Jean Bergounioux
162 Infections Due to Campylobacter and Related Organisms.
Beth D. Kirkpatrick, Martin J. Blaser
163 Cholera and Other Vibrioses.
Matthew K. Waldor, Edward T. Ryan
164 Brucellosis.
Nicholas J. Beeching
165 Tularemia.
Jeannine M. Petersen, Paul S. Mead
166 Plague and Other Yersinia Infections.
Michael B. Prentice
167 Bartonella Infections, Including Cat-Scratch Disease.
Michael Giladi, Moshe Ephros
168 Donovanosis.
Nigel O’Farrell
SECTION 7 Miscellaneous Bacterial Infections
169 Nocardiosis.
Gregory A. Filice
170 Actinomycosis.
Thomas A. Russo
171 Whipple’s Disease.
Thomas A. Russo
172 Infections Due to Mixed Anaerobic Organisms.
Neeraj K. Surana, Dennis L. Kasper
SECTION 8 Mycobacterial Diseases
173 Tuberculosis.
Mario C. Raviglione
174 Leprosy.
Robert H. Gelber
175 Nontuberculous Mycobacterial Infections.
Steven M. Holland
176 Antimycobacterial Agents.
Divya Reddy, Max R. O’Donnell
SECTION 9 Spirochetal Diseases
177 Syphilis.
Sheila A. Lukehart
178 Endemic Treponematoses.
Sheila A. Lukehart
179 Leptospirosis.
Jirˇi F. P. Wagenaar, Marga G. A. Goris
180 Relapsing Fever.
Alan G. Barbour
181 Lyme Borreliosis.
Allen C. Steere
SECTION 10 Diseases Caused by Rickettsiae,
Mycoplasmas, and Chlamydiae
182 Rickettsial Diseases.
David H. Walker, J. Stephen Dumler, Lucas S. Blanton, Thomas Marrie
183 Infections Due to Mycoplasmas.
R. Doug Hardy
184 Chlamydial Infections.
Charlotte A. Gaydos, Thomas C. Quinn
SECTION 11 Viral Diseases: General Considerations
185 Medical Virology.
Fred Wang, Elliott Kieff
186 Antiviral Chemotherapy, Excluding Antiretroviral Drugs.
Lindsey R. Baden
SECTION 12 Infections Due to DNA Viruses
187 Herpes Simplex Virus Infections.
Lawrence Corey
188 Varicella-Zoster Virus Infections.
Richard J. Whitley
189 Epstein-Barr Virus Infections, Including Infectious
Jeffrey I. Cohen
190 Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8.
Camille Nelson Kotton, Martin S. Hirsch
191 Molluscum Contagiosum, Monkeypox, and Other Poxvirus Infections.
Fred Wang
192 Parvovirus Infections.
Kevin E. Brown
193 Human Papillomavirus Infections.
Darron R. Brown, Aaron Ermel
SECTION 13 Infections Due to DNA and RNA
Respiratory Viruses
194 Common Viral Respiratory Infections.
James E. Crowe, Jr.
195 Influenza.
Peter F. Wright
SECTION 14 Infections Due to Human
Immunodeficiency Virus and Other Human
196 The Human Retroviruses.
Dan L. Longo, Anthony S. Fauci
197 Human Immunodeficiency Virus Disease:
AIDS and Related Disorders.
Anthony S. Fauci, Gregory K. Folkers, H. Clifford Lane
SECTION 15 Infections Due to RNA Viruses
198 Viral Gastroenteritis.
Umesh D. Parashar, Roger I. Glass
199 Enterovirus, Parechovirus, and Reovirus Infections.
Jeffrey I. Cohen
200 Measles (Rubeola).
Kaitlin Rainwater-Lovett, William J. Moss
201 Rubella (German Measles).
Laura A. Zimmerman, Susan E. Reef
202 Mumps.
Steven A. Rubin
203 Rabies and Other Rhabdovirus Infections.
Alan C. Jackson
204 Arthropod-Borne and Rodent-Borne Virus Infections.
Jens H. Kuhn, Rémi N. Charrel
205 Ebolavirus and Marburgvirus Infections.
Jens H. Kuhn
SECTION 16 Fungal Infections
206 Diagnosis and Treatment of Fungal Infections.
John E. Edwards, Jr.
207 Histoplasmosis.
Chadi A. Hage, L. Joseph Wheat
208 Coccidioidomycosis.
Neil M. Ampel
209 Blastomycosis.
S. Travis King, Rathel L. Nolan, III
210 Cryptococcosis.
Arturo Casadevall
211 Candidiasis.
John E. Edwards, Jr.
212 Aspergillosis.
David W. Denning
213 Mucormycosis.
Brad Spellberg, Ashraf S. Ibrahim
214 Superficial Mycoses and Less Common Systemic Mycoses.
Carol A. Kauffman
215 Pneumocystis Infections.
Alison Morris, Henry Masur
SECTION 17 Protozoal and Helminthic Infections:
General Considerations
216 Introduction to Parasitic Infections.
Sharon L. Reed, Charles E. Davis
217 Agents Used to Treat Parasitic Infections.
Thomas A. Moore
SECTION 18 Protozoal Infections
218 Amebiasis and Infection with Free-Living Amebae.
Rosa M. Andrade, Sharon L. Reed
219 Malaria.
Nicholas J. White, Elizabeth A. Ashley
220 Babesiosis.
Edouard Vannier, Peter J. Krause
221 Leishmaniasis.
Shyam Sundar
222 Chagas Disease and African Trypanosomiasis.
François Chappuis, Yves Jackson
223 Toxoplasma Infections.
Kami Kim
224 Protozoal Intestinal Infections and Trichomoniasis.
Peter F. Weller
SECTION 19 Helminthic Infections
225 Introduction to Helminthic Infections.
Peter F. Weller
226 Trichinellosis and Other Tissue Nematode Infections.
Peter F. Weller
227 Intestinal Nematode Infections.
Peter F. Weller, Thomas B. Nutman
228 Filarial and Related Infections
Thomas B. Nutman, Peter F. Weller
229 Schistosomiasis and Other Trematode Infections
Birgitte Jyding Vennervald
230 Cestode Infections.
A. Clinton White, Jr., Peter F. Weller
PART 6 Disorders of the Cardiovascular
SECTION 1 Introduction to Cardiovascular
231 Approach to the Patient with Possible Cardiovascular Disease.
Joseph Loscalzo
232 Basic Biology of the Cardiovascular System.
Joseph Loscalzo, Peter Libby, Calum A. MacRae
233 Epidemiology of Cardiovascular Disease.
Thomas A. Gaziano, J. Michael Gaziano
SECTION 2 Diagnosis of Cardiovascular Disorders
234 Physical Examination of the Cardiovascular System.
Patrick T. O’Gara, Joseph Loscalzo
235 Electrocardiography.
Ary L. Goldberger
236 Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging.
Marcelo F. Di Carli, Raymond Y. Kwong, Scott D. Solomon
237 Diagnostic Cardiac Catheterization and Coronary Angiography.
Jane A. Leopold, David P. Faxon
SECTION 3 Disorders of Rhythm
238 Principles of Electrophysiology.
David D. Spragg, Gordon F. Tomaselli
239 The Bradyarrhythmias: Disorders of the Sinoatrial Node.
David D. Spragg, Gordon F. Tomaselli
240 The Bradyarrhythmias: Disorders of the Atrioventricular Node.
David D. Spragg, Gordon F. Tomaselli
241 Approach to Supraventricular Tachyarrhythmias.
Gregory F. Michaud, William G. Stevenson
242 Physiologic and Nonphysiologic Sinus Tachycardia.
Gregory F. Michaud, William G. Stevenson
243 Focal Atrial Tachycardia.
Gregory F. Michaud, William G. Stevenson
244 Paroxysmal Supraventricular Tachycardias.
Gregory F. Michaud, William G. Stevenson
245 Common Atrial Flutter, Macroreentrant, and Multifocal Atrial Tachycardias.
Gregory F. Michaud, William G. Stevenson
246 Atrial Fibrillation.
Gregory F. Michaud, William G. Stevenson
247 Approach to Ventricular Arrhythmias.
Roy M. John, William G. Stevenson
248 Premature Ventricular Beats, Non-Sustained Ventricular Tachycardia, and Idioventricular Rhythm.
Roy M. John, William G. Stevenson
249 Sustained Ventricular Tachycardia.
Roy M. John, William G. Stevenson
250 Polymorphic Ventricular Tachycardia and Ventricular Fibrillation.
Roy M. John, William G. Stevenson
251 Electrical Storm and Incessant VT.
Roy M. John, William G. Stevenson
SECTION 4 Disorders of the Heart
252 Heart Failure: Pathophysiology and Diagnosis.
Douglas L. Mann, Murali Chakinala
253 Heart Failure: Management.
Mandeep R. Mehra
254 Cardiomyopathy and Myocarditis.
Neal K. Lakdawala, Lynne Warner Stevenson,
Joseph Loscalzo
255 Cardiac Transplantation and Prolonged Assisted Circulation.
Mandeep R. Mehra
256 Aortic Valve Disease.
Patrick T. O’Gara, Joseph Loscalzo
257 Aortic Regurgitation.
Patrick T. O’Gara, Joseph Loscalzo
258 Mitral Stenosis.
Patrick T. O’Gara, Joseph Loscalzo
259 Mitral Regurgitation.
Patrick T. O’Gara, Joseph Loscalzo
260 Mitral Valve Prolapse.
Patrick T. O’Gara, Joseph Loscalzo
261 Tricuspid Valve Disease.
Patrick T. O’Gara, Joseph Loscalzo
262 Pulmonic Valve Disease.
Patrick T. O’Gara, Joseph Loscalzo
263 Multiple and Mixed Valvular Heart Disease.
Patrick T. O’Gara, Joseph Loscalzo
264 Congenital Heart Disease in the Adult.
Anne Marie Valente, Michael J. Landzberg
265 Pericardial Disease.
Eugene Braunwald
266 Atrial Myxoma and Other Cardiac Tumors.
Eric H. Awtry
SECTION 5 Coronary and Peripheral Vascular
267 Ischemic Heart Disease.
Elliott M. Antman, Joseph Loscalzo
268 Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina).
Robert P. Giugliano, Christopher P. Cannon, Eugene Braunwald
269 ST-Segment Elevation Myocardial Infarction.
Elliott M. Antman, Joseph Loscalzo
270 Percutaneous Coronary Interventions and Other Interventional Procedures.
David P. Faxon, Deepak L. Bhatt
271 Hypertensive Vascular Disease.
Theodore A. Kotchen
272 Renovascular Disease.
Stephen C. Textor
273 Deep Venous Thrombosis and Pulmonary Thromboembolism.
Samuel Z. Goldhaber
274 Diseases of the Aorta.
Mark A. Creager, Joseph Loscalzo
275 Arterial Diseases of the Extremities.
Mark A. Creager, Joseph Loscalzo
276 Chronic Venous Disease and Lymphedema.
Mark A. Creager, Joseph Loscalzo
277 Pulmonary Hypertension.
Aaron B. Waxman, Joseph Loscalzo
PART 7 Disorders of the Respiratory System
SECTION 1 Diagnosis of Respiratory Disorders
278 Approach to the Patient with Disease of the Respiratory System.
Patricia A. Kritek, Bruce D. Levy
279 Disturbances of Respiratory Function.
Edward T. Naureckas, Julian Solway
280 Diagnostic Procedures in Respiratory Disease.
Anne L. Fuhlbrigge, Augustine M. K. Choi
SECTION 2 Diseases of the Respiratory System
281 Asthma.
Peter J. Barnes
282 Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia.
Praveen Akuthota, Michael E. Wechsler
283 Occupational and Environmental Lung Disease.
John R. Balmes
284 Bronchiectasis.
Rebecca M. Baron, Miriam Baron Barshak
285 Cystic Fibrosis.
Eric J. Sorscher
286 Chronic Obstructive Pulmonary Disease.
Edwin K. Silverman, James D. Crapo, Barry J. Make
287 Interstitial Lung Disease.
Gary M. Hunninghake, Ivan O. Rosas
288 Disorders of the Pleura.
Richard W. Light
289 Disorders of the Mediastinum.
Richard W. Light
290 Disorders of Ventilation.
John F. McConville, Julian Solway, Babak Mokhlesi
291 Sleep Apnea.
Andrew Wellman, Susan Redline
292 Lung Transplantation.
Elbert P. Trulock, III
PART 8 Critical Care Medicine
SECTION 1 Respiratory Critical Care
293 Approach to the Patient with Critical Illness.
John P. Kress, Jesse B. Hall
294 Acute Respiratory Distress Syndrome.
Rebecca M. Baron, Bruce D. Levy
295 Mechanical Ventilatory Support.
Bartolome R. Celli
SECTION 2 Shock and Cardiac Arrest
296 Approach to the Patient with Shock.
Anthony F. Massaro
297 Sepsis and Septic Shock.
Christopher W. Seymour, Derek C. Angus
298 Cardiogenic Shock and Pulmonary Edema.
David H. Ingbar, Holger Thiele
299 Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death.
Christine M. Albert, William G. Stevenson
SECTION 3 Neurologic Critical Care
300 Coma.
S. Andrew Josephson, Allan H. Ropper, Stephen L. Hauser
301 Severe Acute Encephalopathies and Critical Care Weakness.
J. Claude Hemphill, III, Wade S. Smith, S. Andrew Josephson, Daryl R. Gress
302 Subarachnoid Hemorrhage.
J. Claude Hemphill, III, Wade S. Smith, Daryl R. Gress
PART 9 Disorders of the Kidney and Urinary Tract
303 Cellular and Molecular Biology of the Kidney.
Alfred L. George, Jr., Eric G. Neilson
304 Acute Kidney Injury.
Sushrut S. Waikar, Joseph V. Bonventre
305 Chronic Kidney Disease.
Joanne M. Bargman, Karl L. Skorecki
306 Dialysis in the Treatment of Renal Failure.
Kathleen D. Liu, Glenn M. Chertow
307 Transplantation in the Treatment of Renal Failure.
Jamil Azzi, Edgar L. Milford, Mohamed H. Sayegh,
Anil Chandraker
308 Glomerular Diseases.
Julia B. Lewis, Eric G. Neilson
309 Polycystic Kidney Disease and Other Inherited
Disorders of Tubule Growth and Development.
Jing Zhou, Martin R. Pollak
310 Tubulointerstitial Diseases of the Kidney.
Laurence H. Beck, Jr., David J. Salant
311 Vascular Injury to the Kidney.
Ronald S. Go, Nelson Leung
312 Nephrolithiasis.
Gary C. Curhan
313 Urinary Tract Obstruction.
Julian L. Seifter
PART 10 Disorders of the Gastrointestinal System
SECTION 1 Disorders of the Alimentary Tract
314 Approach to the Patient with Gastrointestinal Disease. William L. Hasler, Chung Owyang
315 Gastrointestinal Endoscopy.
Louis Michel Wong Kee Song, Mark Topazian
316 Diseases of the Esophagus.
Peter J. Kahrilas, Ikuo Hirano
317 Peptic Ulcer Disease and Related Disorders.
John Del Valle
318 Disorders of Absorption.
Henry J. Binder
319 Inflammatory Bowel Disease.
Sonia Friedman, Richard S. Blumberg
320 Irritable Bowel Syndrome.
Chung Owyang
321 Diverticular Disease and Common Anorectal Disorders.
Rizwan Ahmed, Susan L. Gearhart
322 Mesenteric Vascular Insufficiency.
Satinderjit Locham, Mahmoud Malas
323 Acute Intestinal Obstruction.
Danny O. Jacobs
324 Acute Appendicitis and Peritonitis.
Danny O. Jacobs
SECTION 2 Nutrition
325 Nutrient Requirements and Dietary Assessment.
Johanna Dwyer
326 Vitamin and Trace Mineral Deficiency and Excess.
Paolo M. Suter, Robert M. Russell
327 Malnutrition and Nutritional Assessment.
Gordon L. Jensen
328 Enteral and Parenteral Nutrition.
L. John Hoffer, Bruce R. Bistrian, David F. Driscoll
SECTION 3 Liver and Biliary Tract Disease
329 Approach to the Patient with Liver Disease.
Marc G. Ghany, Jay H. Hoofnagle
330 Evaluation of Liver Function.
Daniel S. Pratt
331 The Hyperbilirubinemias.
Allan W. Wolkoff
332 Acute Viral Hepatitis.
Jules L. Dienstag
333 Toxic and Drug-Induced Hepatitis.
William M. Lee, Jules L. Dienstag
334 Chronic Hepatitis.
Jules L. Dienstag
335 Alcoholic Liver Disease.
Mark E. Mailliard, Michael F. Sorrell
336 Nonalcoholic Fatty Liver Diseases and Nonalcoholic Steatohepatitis.
Manal F. Abdelmalek, Anna Mae Diehl
337 Cirrhosis and Its Complications.
Bruce R. Bacon
338 Liver Transplantation.
Raymond T. Chung, Jules L. Dienstag
339 Diseases of the Gallbladder and Bile Ducts.
Norton J. Greenberger, Gustav Paumgartner
SECTION 4 Disorders of the Pancreas
340 Approach to the Patient with Pancreatic Disease.
Darwin L. Conwell, Norton J. Greenberger, Peter A. Banks
341 Acute and Chronic Pancreatitis.
Darwin L. Conwell, Peter A. Banks, Norton J. Greenberger
PART 11 Immune-Mediated, Inflammatory, and Rheumatologic Disorders
SECTION 1 The Immune System in Health and Disease
342 Introduction to the Immune System.
Barton F. Haynes, Kelly A. Soderberg, Anthony S. Fauci
343 The Major Histocompatibility Complex.
Gerald T. Nepom
344 Primary Immune Deficiency Diseases.
Alain Fischer
SECTION 2 Disorders of Immune-Mediated Injury
345 Urticaria, Angioedema, and Allergic Rhinitis.
Katherine N. Cahill, Joshua A. Boyce
346 Anaphylaxis.
David Hong, Joshua A. Boyce
347 Mastocytosis.
Cem Akin, Joshua A. Boyce
348 Autoimmunity and Autoimmune Diseases.
Betty Diamond, Peter E. Lipsky
349 Systemic Lupus Erythematosus.
Beira Hannahs Hahn
350 Antiphospholipid Syndrome.
Haralampos M. Moutsopoulos
351 Rheumatoid Arthritis.
Ankoor Shah, E. William St. Clair
352 Acute Rheumatic Fever.
Jonathan R. Carapetis
353 Systemic Sclerosis (Scleroderma) and Related Disorders.
John Varga
354 Sjögren’s Syndrome.
Haralampos M. Moutsopoulos
355 The Spondyloarthritides.
Joel D. Taurog
356 The Vasculitis Syndromes.
Carol A. Langford, Anthony S. Fauci
357 Behçet’s Syndrome.
Haralampos M. Moutsopoulos
358 Inflammatory Myopathies.
Steven A. Greenberg, Anthony A. Amato
359 Relapsing Polychondritis.
Carol A. Langford
360 Sarcoidosis.
Robert P. Baughman, Elyse E. Lower
361 IgG4-Related Disease.
John H. Stone
362 Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases.
Daniel L. Kastner
SECTION 3 Disorders of the Joints and Adjacent Tissues
363 Approach to Articular and Musculoskeletal Disorders.
John J. Cush
364 Osteoarthritis.
David T. Felson, Tuhina Neogi
365 Gout and Other Crystal-Associated Arthropathies.
H. Ralph Schumacher, Lan X. Chen
366 Fibromyalgia.
Leslie J. Crofford
367 Arthritis Associated with Systemic Disease, and Other Arthritides.
Carol A. Langford, Brian F. Mandell
368 Periarticular Disorders of the Extremities.
Carol A. Langford
PART 12 Endocrinology and Metabolism
SECTION 1 Endocrinology
369 Approach to the Patient with Endocrine Disorders.
J. Larry Jameson
370 Mechanisms of Hormone Action.
J. Larry Jameson
371 Physiology of Anterior Pituitary Hormones.
Shlomo Melmed, J. Larry Jameson
372 Hypopituitarism.
Shlomo Melmed, J. Larry Jameson
373 Pituitary Tumor Syndromes.
Shlomo Melmed, J. Larry Jameson
374 Disorders of the Neurohypophysis.
Gary L. Robertson
375 Thyroid Gland Physiology and Testing.
J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
376 Hypothyroidism.
J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
377 Hyperthyroidism.
J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
378 Thyroid Nodular Disease and Thyroid Cancer.
J. Larry Jameson, Susan J. Mandel, Anthony P. Weetman
379 Disorders of the Adrenal Cortex.
Wiebke Arlt
380 Pheochromocytoma.
Hartmut P. H. Neumann
381 Multiple Endocrine Neoplasia.
R. V. Thakker
382 Autoimmune Polyendocrine Syndromes.
Peter A. Gottlieb, Aaron W. Michels
SECTION 2 Sex- and Gender-Based Medicine
383 Disorders of Sex Development.
John C. Achermann, J. Larry Jameson
384 Disorders of the Testes and Male Reproductive System.
Shalender Bhasin, J. Larry Jameson
385 Disorders of the Female Reproductive System.
Janet E. Hall
386 Menstrual Disorders and Pelvic Pain.
Janet E. Hall
387 Hirsutism.
David A. Ehrmann
388 Menopause and Postmenopausal Hormone Therapy.
JoAnn E. Manson, Shari S. Bassuk
389 Infertility and Contraception.
Janet E. Hall
390 Sexual Dysfunction.
Kevin T. McVary
391 Women’s Health.
Andrea Dunaif
392 Men’s Health.
Shalender Bhasin, Shehzad Basaria
393 Lesbian, Gay, Bisexual, and Transgender (LGBT) Health.
Baligh R. Yehia, Harvey J. Makadon
SECTION 3 Obesity, Diabetes Mellitus, and
Metabolic Syndrome
394 Pathobiology of Obesity.
Jeffrey S. Flier, Eleftheria Maratos-Flier
395 Evaluation and Management of Obesity.
Robert F. Kushner
396 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology.
Alvin C. Powers, Kevin D. Niswender, Carmella Evans-Molina
397 Diabetes Mellitus: Management and Therapies.
Alvin C. Powers, Kevin D. Niswender, Michael R. Rickels
398 Diabetes Mellitus: Complications.
Alvin C. Powers, John M. Stafford, Michael R. Rickels
399 Hypoglycemia.
Philip E.Cryer, Stephen N. Davis
400 Disorders of Lipoprotein Metabolism.
Daniel J. Rader, Sekar Kathiresan
401 The Metabolic Syndrome.
Robert H. Eckel
SECTION 4 Disorders of Bone and Mineral Metabolism
402 Bone and Mineral Metabolism in Health and Disease.
F. Richard Bringhurst, Marie B. Demay, Henry M. Kronenberg
403 Disorders of the Parathyroid Gland and Calcium Homeostasis.
John T. Potts, Jr., Harald W. Jüppner
404 Osteoporosis.
Robert Lindsay, Felicia Cosman
405 Paget’s Disease and Other Dysplasias of Bone.
Murray J. Favus, Tamara J. Vokes
SECTION 5 Disorders of Intermediary Metabolism
406 Heritable Disorders of Connective Tissue.
Darwin J. Prockop, John F. Bateman
407 Hemochromatosis.
Lawrie W. Powell
408 Wilson’s Disease.
George J. Brewer
409 The Porphyrias.
Robert J. Desnick, Manisha Balwani
410 Disorders of Purine and Pyrimidine Metabolism.
John N. Mecchella, Christopher M. Burns
411 Lysosomal Storage Diseases.
Robert J. Hopkin, Gregory A. Grabowski
412 Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism.
Priya S. Kishnani, Yuan-Tsong Chen
413 Inherited Disorders of Amino Acid Metabolism in Adults.
Nicola Longo
414 Inherited Defects of Membrane Transport.
Nicola Longo
PART 13 Neurologic Disorders
SECTION 1 Diagnosis of Neurologic Disorders
415 Approach to the Patient with Neurologic Disease.
Daniel H. Lowenstein, Joseph B. Martin, Stephen L. Hauser
416 Neuroimaging in Neurologic Disorders.
William P. Dillon
417 Pathobiology of Neurologic Diseases.
Stephen L. Hauser, Arnold R. Kriegstein, Stanley B. Prusiner
SECTION 2 Diseases of the Central Nervous System
418 Seizures and Epilepsy.
Daniel H. Lowenstein
419 Cerebrovascular Diseases.
Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III
420 Ischemic Stroke.
Wade S. Smith, S. Claiborne Johnston, J. Claude Hemphill, III
421 Intracranial Hemorrhage.
Wade S. Smith, J. Claude Hemphill, III, S. Claiborne Johnston
422 Migraine and Other Primary Headache Disorders.
Peter J. Goadsby
423 Alzheimer’s Disease.
William W. Seeley, Bruce L. Miller
424 Frontotemporal Dementia.
William W. Seeley, Bruce L. Miller
425 Vascular Dementia.
Joel Kramer, William W. Seeley, Bruce L. Miller
426 Dementia with Lewy Bodies.
William W. Seeley, Caroline M. Tanner, Bruce L. Miller
427 Parkinson’s Disease.
C. Warren Olanow, Christine Klein, Anthony H. V. Schapira
428 Tremor, Chorea, and Other Movement Disorders.
C. Warren Olanow, Christine Klein, Jose A. Obeso
429 Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases.
Robert H. Brown, Jr.
430 Prion Diseases.
Stanley B. Prusiner, Bruce L. Miller
431 Ataxic Disorders.
Roger N. Rosenberg
432 Disorders of the Autonomic Nervous System.
Christopher H. Gibbons, John W. Engstrom
433 Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders.
M. Flint Beal, Stephen L. Hauser
434 Diseases of the Spinal Cord.
Stephen L. Hauser
435 Concussion and Other Traumatic Brain Injuries.
Geoffrey T. Manley, Stephen L. Hauser, Michael McCrea
436 Multiple Sclerosis.
Bruce A. C. Cree, Stephen L. Hauser
437 Neuromyelitis Optica.
Bruce A. C. Cree, Stephen L. Hauser
SECTION 3 Nerve and Muscle Disorders
438 Peripheral Neuropathy.
Anthony A. Amato, Richard J. Barohn
439 Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies.
Stephen L. Hauser, Anthony A. Amato
440 Myasthenia Gravis and Other Diseases of the Neuromuscular Junction.
Anthony A. Amato
441 Muscular Dystrophies and Other Muscle Diseases.
Anthony A. Amato, Robert H. Brown, Jr.
SECTION 4 Chronic Fatigue Syndrome
442 Chronic Fatigue Syndrome.
Gijs Bleijenberg, Jos W. M. van der Meer
SECTION 5 Psychiatric and Addiction Disorders
443 Biology of Psychiatric Disorders.
Robert O. Messing, Eric J. Nestler, Matthew W. State
444 Psychiatric Disorders.
Victor I. Reus
445 Alcohol and Alcohol Use Disorders.
Marc A. Schuckit
446 Opioid-Related Disorders.
Thomas R. Kosten, Colin N. Haile
447 Cocaine and Other Commonly Used Drugs.
Karran A. Phillips, Antonello Bonci
448 Nicotine Addiction.
David M. Burns
PART 14 Poisoning, Drug Overdose, and Envenomation
449 Heavy Metal Poisoning.
Howard Hu
450 Poisoning and Drug Overdose.
Mark B. Mycyk
451 Disorders Caused by Venomous Snakebites and
Marine Animal Exposures.
Charles Lei, Kirsten B. Hornbeak, Paul S. Auerbach, Robert L. Norris
452 Ectoparasite Infestations and Arthropod Injuries.
Richard J. Pollack, Scott A. Norton
PART 15 Disorders Associated with Environmental Exposures
453 Altitude Illness.
Buddha Basnyat, Geoffrey Tabin
454 Hypothermia and Peripheral Cold Injuries.
Daniel F. Danzl
455 Heat-Related Illnesses.
Daniel F. Danzl
PART 16 Genes, the Environment, and Disease
456 Principles of Human Genetics.
J. Larry Jameson, Peter Kopp
457 The Practice of Genetics in Clinical Medicine.
Susan M. Domchek, J. Larry Jameson, Susan Miesfeldt
458 Gene and Cell-Based Therapy in Clinical Medicine.
Katherine A. High, Malcolm K. Brenner
459 The Human Microbiome.
Neeraj K. Surana, Dennis L. Kasper
PART 17 Global Medicine
460 Global Issues in Medicine.
Joseph J. Rhatigan, Paul Farmer
461 Worldwide Changes in Patterns of Infectious Disease.
George W. Rutherford, Jaime Sepulveda
462 Primary Care and Global Health.
Tim Evans, Kumanan Rasanathan
PART 18 Aging
463 The Biology of Aging.
Rafael de Cabo, David G. Le Couteur
464 Clinical Problems Associated with the Aging Process.
Joseph G. Ouslander, Bernardo Reyes
PART 19 Consultative Medicine
465 Approach to Medical Consultation.
Jack Ende, Jeffrey Berns
466 Medical Disorders During Pregnancy.
Robert L. Barbieri, John T. Repke
467 Medical Evaluation of the Surgical Patient.
Prashant Vaishnava, Kim A. Eagle
PART 20 Frontiers
468 Behavioral Economics and Health.
Kevin G. Volpp, George Loewenstein, David A. Asch
469 Complementary, Alternative, and Integrative Health Approaches.
Josephine P. Briggs
470 Telomere Disease.
Rodrigo T. Calado, Neal S. Young
471 The Role of Epigenetics in Disease and Treatment.
Brian C. Capell, Shelley L. Berger
472 Mitochondrial DNA and Heritable Traits and Diseases.
Karl L. Skorecki, Bruce H. Cohen
473 Applications of Stem Cell Biology in Clinical Medicine.
John A. Kessler
474 Microbial Genomics and Infectious Disease.
Roby P. Bhattacharyya, Yonatan H. Grad, Deborah T. Hung
475 The Role of Circadian Biology in Health and Disease.
Jonathan Cedernaes, Kathryn Moynihan Ramsey, Joseph Bass
476 Network Medicine: Systems Biology in Health and Disease.
Joseph Loscalzo
477 Emerging Neurotherapeutic Technologies.
Jyoti Mishra, Karunesh Ganguly

About the author:

J. Larry Jameson, MD, Ph.D. Robert G. Dunlop Professor of Medicine; Dean, Raymond and Ruth Perelman School of Medicine; Executive Vice President, the University of Pennsylvania for the Health System, Philadelphia, Pennsylvania.

Anthony S. Fauci, MD. Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

Dennis L. Kasper, MD. William Ellery Channing Professor of Medicine and Professor of Microbiology and Immunobiology, Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts.

Stephen L. Hauser, MD. Director, UCSF Weill Institute for Neurosciences; Robert A. Fishman Distinguished Professor, Department of Neurology, University of California, San Francisco, San Francisco, California.

Dan L. Longo, MD. Professor of Medicine, Harvard Medical School; Senior Physician, Brigham and Women’s Hospital; Deputy Editor, New England Journal of Medicine, Boston, Massachusetts.

Joseph Loscalzo, MD, Ph.D. Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine; Physician-in-Chief, Brigham and Women’s Hospital, Boston, Massachusetts.

Reviews about the ebook:

  • Iron Duke
    One of the best and the go-to resource for Internal Medicine and the 20th edition is only better. The eChapters from the previous edition have been converted to a print format which is similar to the format followed before the 19th edition. Using sources like Update is great for point of care refresh of knowledge and revision but this is a textbook that will help build a solid foundation of knowledge which is critical to any practicing physician. Before anyone says that it is too voluminous, know that most medical students and residents in India finish this book cover to cover before graduating from residency.
  • Hamid Mukhtar:
    I was really excited to see the edition of this classic textbook. I was hoping to read all the cutting-edge information. The price of the Kindle edition is almost the same as the physical book but none of the videos or other supplemental material is available to the buyers unless they subscribe to access medicine. To test how recent the updates were, I tested out the subject of hypertension. Although the current hypertension guidelines were published in October 2017, this edition published in the second half of 2018 still does not mention them and uses the old classification of hypertension from 2003. I wonder if other topics have the same fate. So I can’t trust the latest edition to get the latest information.
  • Paul V. KATCHALOV:
    For many decades years, it is medical manual No 1 throughout the World. On my 60-years anniversary, I purchased the new edition to be up-to-date in my medical mind: and my expectations were not deceived.
  • Billy Dibbles:
    I’m not a doctor or even close as I’m only a second-year cell and molec bio undergrad but I love these books. Two reasons. I learn some of the biology and bits of physio in school but these books show me how it can apply to the real world and in everyday clinical situations. Also, I have my own health problems and I consult these all the time and the flow charts have helped me treat myself when I don’t have access to an M.D. The first time I had an Addison’s disease crisis I didn’t understand what was happening and had the section bookmarked. I was really out of it but I saw the bookmark and just did what it said with hydrocortisone and electrolytes and was able to get out of my bed finally and to the E.R soon after for real help.
  • AJP:
    There are two main general internal medicine textbooks: Cecil and Harrison’s. Each has some strengths and weaknesses, and the choice is one of general preference. In these days of UpToDate (yeah, a plug for those guys) where entries can be rapidly updated, the utility of a giant, high-mass paper textbook has been called into question. These guys still give more comprehensive coverage of all topics, assuming your lips don’t get tired after reading the first few pages.
  • Carlos Valadez:
    I am a recently qualified Doctor and purchased these books with two main aims;
    1) as the main textbook for a distance learning MSc Internal Medicine, and,
    2) to support study for higher-level professional exams/application exams (e.g., MSRA). Plus, it’s also nice to have a good set of comprehensive reference books at home.CONTENT: Clearly, just looking at the size alone, this book has very comprehensive coverage. I haven’t used the textbooks enough to comment upon the technical content, but at glance, it appears to cover the required depth/breadth required at my level.Each section has a good balance of images/diagrams and text. It’s a little too verbose for my liking but that is a personal preference (why use 300 words when a few bullet points convey the exact same information?).

    QUALITY OF CONSTRUCTION: The comments raised in other reviews about the page quality are correct. The pages are far too thin. Print from the other side of the page can be read through the page. This happens even when the page is flat – i.e. not just held up to allow light to pass through. It is important to be very deliberate and delicate when turning pages as it will be very easy to tear the pages. The issue is made worse by the size of the book – when you flip to halfway through the book there’s a lot of weight in the pages and it will be very easy to damage the book.

    In my opinion, this textbook set would be much better than a 3 volume set with slightly thicker pages.

    The print quality on each page, however, is good. The text is small in size but clear and sharp. The quality of the images is adequate.

    PRICE: This is an expensive textbook! However, I do think it offers better value in comparison to alternatives such as the Oxford Textbook.

  • Mo Aye:
    I grew up learning medicine with Harrison’s. I have bought every edition since the 11th. This 20th edition will not disappoint its long-established fan base. The content has been thoroughly revised and refreshed. The prose is concise, clear, and consistent. It is easy and pleasurable to read. The clarity of thought makes it the premier textbook for all students of internal medicine. The clinical practice is very much American, but the general principles are relevant to practitioners anywhere in the world. The 20th edition is bulkier than the 19th (3528 pages of 2770 pages excluding indices): the chapters available only in electronic form in the 19th are now back in prin. Three are numerous new chapters and topics. The only minor gripes are that (a) the paper is probably too thin (this appears to be the trade-off for keeping the volumes thin and light enough to hold), and (b) online access is only through subscription. Neither should detract from the sheer joy of reading this refreshed classic.
  • China Merchants Bank:
    There are more than 30 Harrison series books published in China, include 18 version, 19 version, I am glad to get the 20th version, very useful to our scientist and physicians
  • Utpal Singh:
    The Bible of medicine. Unmatched in the information and coverage.

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